Rabeprazole + Domperidone: Why DSR Leads India's Gastro Prescriptions & Bihar Chemist Rate Guide
HAMZTOP DSR — Rabeprazole Sodium IP 20mg (enteric coated pellets) + Domperidone IP 30mg (sustained release pellets) — is distributed directly to licensed chemists in Siwan, Gopalganj, and Saran (Chhapra), Bihar by Herophil Pharma Private Limited, from its central operational depot at Sir Sayed Chowk, Sukla Toll, Siwan – 841226. Chemists earn a solid 40%+ gross margin (vs. 12–16% on national C&F brands) with 24–48 hour road dispatch, full Input Tax Credit (ITC), and Form 20B/21B billing. Official MRP is ₹135 per strip (10 capsules, Alu-Alu) with direct depot net rate (PTR) at ₹79.00, delivering ~₹56 profit per strip.
HAMZTOP DSR Capsules
Rabeprazole Sodium IP 20mg (EC) + Domperidone IP 30mg (SR) in 10x10 Alu-Alu Blisters. Moisture-barrier packaging engineered for North Bihar weather.
Figure 1.0: Authentic HAMZTOP DSR outer carton & Alu-Alu blister packaging with stomach graphic and Schedule H caution declarations.
The Molecular Science of HAMZTOP DSR — Why Pellet Technology Drives Counter Sales
If you typed "rabeprazole domperidone capsule rate Bihar" or "DSR capsule wholesale Siwan" into Google, you already know the problem: page after page of out-of-state IndiaMART listings from Ahmedabad, Vadodara, and Mohali traders quoting ₹75–₹210 per strip with MOQs of 500–5,000 boxes you will never lift from Siwan; JustDial phone-number dumps with no composition, no PTR, no license details; and generic PCD franchise template sites with no office in Bihar, no Bihar drug license discussion, and 10–14 day transit from Himachal or Chandigarh.
The Pharmacokinetic Problem This Capsule Solves
Rabeprazole is a proton pump inhibitor (PPI) — it is acid-labile, meaning it is chemically degraded by the very gastric acid it is prescribed to suppress. A plain rabeprazole tablet loses a significant fraction of its active dose in the acidic stomach environment. HAMZTOP DSR solves this the same way the top national brands do: enteric coated pellets that remain completely intact at gastric pH (~1.5–3.5) and dissolve only in the alkaline environment of the duodenum and jejunum (pH > 5.5), where rabeprazole is safely absorbed to irreversibly inhibit the H+/K+ ATPase enzyme system.
Domperidone is a peripheral dopamine D2-receptor antagonist and prokinetic agent — it accelerates gastric emptying and increases lower esophageal sphincter tone, preventing the acid regurgitation patients describe as "chhati mein jalan aur khatti dakar." However, standard domperidone has a short half-life requiring multiple daily doses. HAMZTOP DSR incorporates sustained release (SR) pellets, releasing domperidone steadily over 12+ hours for true once-daily dosing. Once-daily dosing drives patient compliance, which drives repeat chemist sales.
Carton & Batch Regulatory Specifications
| Carton Declaration | Exact Specification |
|---|---|
| Active Composition | Rabeprazole Sodium IP 20mg (as enteric coated pellets) + Domperidone IP 30mg (as sustained release pellets) |
| Dosage Form | Domperidone Sustained Release (DSR) Hard Gelatin Capsule |
| Packaging Specification | 10 x 10 Capsules, Alu-Alu Blister (Cold-formed aluminium-aluminium moisture barrier) |
| Maximum Retail Price (MRP) | ₹135.00 per strip of 10 capsules (inclusive of all taxes) |
| Wholesale Net Rate (PTR) | ₹79.00 per strip (Direct Siwan Depot Wholesale Billing) |
| Chemist Gross Margin | ₹56.00 per strip (41.5% — Solid 40%+ Margin) |
| Storage Condition | Store below 25°C in a cool, dry & dark place; protect from light and moisture |
| Drug Schedule | Schedule H Prescription Drug — Dispense strictly against RMP prescription |
| Legal Trademark | HAMZTOP-DSR® (TM No. 5783783, Class 5, Trade Marks Registry Mumbai, Govt. of India) |
| Central Depot Hub | Sir Sayed Chowk, Sukla Toll, Siwan, Bihar – 841226 |
* Alu-Alu blister packaging provides an impermeable moisture barrier, preventing pellet softening in North Bihar monsoon conditions.
Ground-Level Bihar Market Reality — Why DSR Is Your Fastest-Moving Strip
Any chemist across Siwan town, Mairwa, Maharajganj, or Gopalganj knows from daily register records: the DSR capsule is a daily-rotation product, not a slow-moving specialty line. Structural factors guarantee sustained velocity:
Traditional North Bihar dietary habits — mustard oil preparations, heavy pulses, irregular tea consumption, and late dinners — create high rates of hyperacidity, epigastric fullness, and functional dyspepsia.
North Bihar has an exceptionally high concentration of Registered Medical Practitioners (RMPs), primary care physicians, and gastroenterologists who prescribe Rabeprazole + Domperidone as the empirical first-line choice.
When a chronic acid reflux patient needs a 15-day course, an MRP of ₹235+ on national brands forces many to drop therapy early. At ₹135 MRP, HAMZTOP DSR is immediately affordable for everyday families, ensuring full course completion.
DSR is not a slow-moving specialty; an average medical store in Siwan moves 20 to 50 strips every week, making high PTR margins translate directly into major monthly store profits.
Where Your 12–16% Actually Goes — Traditional Multi-Tier vs. Direct Depot
National C&F brands reach Bihar through 4 intermediate layers — pharmaceutical manufacturer → C&F clearing agent → state super-stockist → district wholesaler → retail chemist. Each layer extracts 5–8%, while adding 10–14 days of transit delay. Herophil Pharma's direct depot model at Sir Sayed Chowk, Siwan cuts all intermediate middlemen, delivering within 24–48 hours and passing those margins directly to the retail chemist as a 40%+ gross margin.
Trade Economics: National C&F Brands vs. Herophil Direct Depot
| Commercial Parameter | National C&F Brand | HAMZTOP DSR (Direct Depot) | Chemist Advantage |
|---|---|---|---|
| Strip MRP (10 SR Capsules) | ₹226.00 – ₹255.00 | ₹135.00 | ₹90–₹120 lower for patient |
| Chemist Purchase Rate (PTR) | ₹190.00 – ₹215.00 | ₹79.00 | Direct manufacturer billing |
| Chemist Gross Margin per Strip | ₹25.00 – ₹38.00 (12–16%) | ₹56.00 (41.5% — 40%+) | +₹18 to +₹31 extra profit/strip |
| Dispatch Timeline to Siwan | 7–14 days from indent | 24–48 hours direct road dispatch | Same-week stock turn |
| Mid-Week Stock-Out Risk | Chronic in Tier-3 towns | Near zero (depot inventory in Siwan) | 100% order fill rate |
| GST Input Tax Credit (ITC) | Standard | Full GST Invoice with 100% ITC | Clean audit compliance |
| Wholesale License Basis | Multi-tier distributor bills | Direct Form 20B/21B Depot Invoice | Inspectable FDA trail |
Test Your Own Medical Store's Numbers Below
Chemist PTR Profit Calculator & Supply Chain Comparison
See why medical shop owners across Siwan, Gopalganj, and Saran are switching from national C&F-distributed brands to direct depot supply.
Traditional Multi-Tier C&F Model vs. Herophil Direct Supply
The Cost to Bihar Chemists:
• 10 to 14 days transit delay leads to frequent stock-outs & patient loss.
• Multiple distributor margins cut your profit down to just ₹35–₹40 per strip.
The Herophil Direct Advantage:
• Direct depot billing passes all intermediary C&F margins directly to you.
• Same-week replenishment ensures you never turn an acid-reflux patient away.
• 100% genuine Class 5 Trademark (TM No. 5783783) protects your Drug License.
Calculate Your Extra Monthly Profit on HAMZTOP DSR
💡 Slide to adjust your medical store's approximate monthly sale of DSR capsules.
+₹8,000 Extra Net Profit Every Month
That equals +₹96,000 extra pure profit annually retained in your medical store simply by eliminating out-of-state middlemen.
National Brand Equivalents & Honest Counter Substitution
Razo-D (Dr. Reddy's), Veloz-D (Torrent), and Rabicip-D (Cipla) contain Rabeprazole Sodium 20mg (EC) + Domperidone 30mg (SR) — identical active salts and pellet technologies to HAMZTOP DSR. They differ in pricing (₹226–₹255 MRP) and multi-layer distributor costs. HAMZTOP DSR provides equivalent clinical efficacy at an honest ₹135 MRP with 40%+ chemist margin.
| Brand Name | Company | Active Formulation | MRP (10 Caps) | Chemist Margin |
|---|---|---|---|---|
| Razo-D | Dr. Reddy's Laboratories | Rabeprazole 20mg EC + Domperidone 30mg SR | ₹235.00 | ~15% (₹35) |
| Veloz-D | Torrent Pharmaceuticals | Rabeprazole 20mg EC + Domperidone 30mg SR | ₹226.50 | ~16% (₹36) |
| Rabicip-D | Cipla Ltd | Rabeprazole 20mg EC + Domperidone 30mg SR | ₹230.00 | ~15% (₹34) |
| HAMZTOP DSR | Herophil Pharma Pvt Ltd | Rabeprazole 20mg EC + Domperidone 30mg SR | ₹135.00 | 40%+ (₹56) |
When a patient presents a brand-specific prescription for Razo-D or Veloz-D, dispense exactly what the doctor prescribed. However, when patients present generic salt scripts or ask for an affordable, high-efficacy alternative, HAMZTOP DSR provides the identical bioequivalent molecule, saves the patient ~₹100 per strip, and delivers 2.5× the profit margin to your medical store.
Protecting Your Chemist Drug License — Compliance First
In Bihar's stringent regulatory environment, stocking unverified trader labels or grey-market medicines puts your Form 20/21 Retail Drug License at severe risk. Herophil Pharma provides complete legal protection:
Verified registration under TM No. 5783783 (Class 5 — Medicinal and Pharmaceutical Preparations). Spurious brands cannot produce official trademark gazette certificates.
We bill directly from our authorized depot under valid wholesale drug licenses issued by FDA Bihar. No informal slips, no unverifiable cash chits.
Every invoice carries our registered GSTIN, allowing retail chemists to claim full input credit on tax paid — recovering an immediate 5% to 12% in tax offsets.
How to Order Stock or Secure Territory Monopoly in Bihar (Step-by-Step)
WhatsApp Direct Message
Message our commercial sales desk at +91 90061 16777 with your medical store name, town/block, Drug License number, and GSTIN.
Receive Net PTR Rate Card
We immediately send you the confirmed wholesale net rate card for HAMZTOP DSR and companion formulations.
Place Opening Trial Order
No 500-box MOQs. Opening orders start from just 2 to 5 boxes of 10x10 so your counter liquidity remains untouched.
Direct Road Delivery (24-48 Hours)
Stock is packed and dispatched from Sir Sayed Chowk, Siwan depot with an authentic Form 20B bill and GST ITC.
Territory Monopoly Application
Apply for exclusive block or district-level monopoly rights under our PCD Pharma Franchise Program after trial order verification.
Chemist & Stockist FAQs (Straight Commercial Answers)
What is the official wholesale net rate (PTR) and chemist margin on HAMZTOP DSR in Bihar?
HAMZTOP DSR carries an official MRP of ₹135.00 per strip of 10 capsules (Alu-Alu blister). Direct Siwan depot supply gives licensed chemists a wholesale net rate (PTR) of ₹79.00, yielding a solid 41.5% gross chemist margin (~₹56.00 profit per strip), compared to just 12–16% (~₹35) on national C&F brands.
Who is the authorized distributor for HAMZTOP DSR in Siwan, Gopalganj, and Chhapra?
Herophil Pharma Private Limited distributes HAMZTOP DSR directly from its central operational depot at Sir Sayed Chowk, Sukla Toll, Siwan, Bihar – 841226. Local road delivery ensures same-day to 48-hour fulfillment across Siwan, Gopalganj, and Saran. Orders and inquiries are handled via WhatsApp at +91 90061 16777.
Can retail chemists and prescribing doctors receive free clinical samples?
Yes. Licensed retail pharmacies, RMP clinics, and specialist gastroenterologists in our active distribution zones (Siwan, Saran, Gopalganj) can request sample strips and visual aids directly through our WhatsApp sales desk. Samples are dispatched within 24–48 hours from our Siwan depot.
What drug licenses are mandatory to purchase HAMZTOP DSR?
Purchasers must hold a valid Form 20/21 Retail Drug License (or Form 20B/21B Wholesale License) issued by the Food and Drugs Administration, along with a registered GSTIN. As a Schedule H prescription drug, HAMZTOP DSR must be dispensed only against a registered doctor's prescription.
Can I get exclusive monopoly rights for HAMZTOP DSR in my block or district?
Yes. Herophil Pharma grants protected block and district monopoly rights to qualified stockists and PCD partners. Monopoly partners receive territorial exclusivity, promotional inputs, and direct depot billing protection. Inquire via our PCD Franchise Desk or WhatsApp +91 90061 16777.